Interleukin 10 Receptor, Alpha

Alternative Names

IL10RA
Interleukin 10 Receptor
IL10R
IL10R1

Length

16,690 bases

No. of Exons

No. of isoforms

Protein Name

Interleukin-10 receptor subunit alpha

Molecular Mass

63003 Da

Amino Acid Count

578

Genomic Location

chr11:117,986,348-118,003,037

Gene Map Locus

11q23.3

Description

The IL10RA gene codes for the alpha subunit of the interluekin 10 receptor. It mediates the anti-inflammatory propertiy of interleukin 10 through activation of JAK1 and TYK2 kinases.

Mutations in this gene are known to cause a form of inflammatory bowel disease, IBD28.

Epidemiology in the Arab World

View Map

Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001558.3:c.1051A>G	Lebanon	chr11:117998955	Benign	Benign	Inflammatory Bowel Disease 1	NG_016275.1:g.17565A>G; NM_001558.3:c.1051A>G; NP_001549.2:p.Arg351Gly	2229113	302554
NM_001558.3:c.421G>A	Lebanon	chr11:117993294	Pathogenic	Pathogenic	Inflammatory Bowel Disease 28, Autosomal Recessive	NG_016275.1:g.11904G>A ; NM_001558.3:c.421G>A; NP_001549.2:p.Gly141Arg	137853579	14814
NM_001558.3:c.475A>G	Lebanon	chr11:117993348	Benign, Likely Benign	Benign	Inflammatory Bowel Disease 1	NG_016275.1:g.11958A>G; NM_001558.3:c.475A>G; NP_001549.2:p.Ser159Gly	3135932	197197
NM_001558.4:c.172G>A	Lebanon	chr11:117988486	Likely Benign	Likely Pathogenic	Inflammatory Bowel Disease 28, Autosomal Recessive	NG_016275.1:g.7096G>A; NM_001558.4:c.172G>A; NP_001549.2:p.Glu58Lys	572945136	733184

Download Table

External Links

https://ghr.nlm.nih.gov/gene/IL10RA https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL10RA https://www.ncbi.nlm.nih.gov/gene/3587

Contributors

Pratibha Nair: 16.11.2020
Pratibha Nair: 12.05.2020
Pratibha Nair: 28.08.2019

Edit History

Pratibha Nair: 16.11.2020
Pratibha Nair: 12.05.2020
Pratibha Nair: 28.08.2019
Pratibha Nair: 07.12.2014

Back to search Result