Interleukin 10 Receptor, Alpha

Alternative Names

IL10RA
Interleukin 10 Receptor
IL10R
IL10R1

Length

16,690 bases

No. of Exons

No. of isoforms

Protein Name

Interleukin-10 receptor subunit alpha

Molecular Mass

63003 Da

Amino Acid Count

578

Genomic Location

chr11:117,986,348-118,003,037

Gene Map Locus

11q23.3

Description

The IL10RA gene codes for the alpha subunit of the interluekin 10 receptor. It mediates the anti-inflammatory propertiy of interleukin 10 through activation of JAK1 and TYK2 kinases.

Mutations in this gene are known to cause a form of inflammatory bowel disease, IBD28.

Epidemiology in the Arab World

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Lebanon

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Search:

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001558.3:c.1051A>G	Lebanon	chr11:117998955	Benign	Benign	Inflammatory Bowel Disease 1	NG_016275.1:g.17565A>G; NM_001558.3:c.1051A>G; NP_001549.2:p.Arg351Gly	2229113	302554
NM_001558.3:c.421G>A	Lebanon	chr11:117993294	Pathogenic	Pathogenic	Inflammatory Bowel Disease 28, Autosomal Recessive	NG_016275.1:g.11904G>A ; NM_001558.3:c.421G>A; NP_001549.2:p.Gly141Arg	137853579	14814
NM_001558.3:c.475A>G	Lebanon	chr11:117993348	Benign, Likely Benign	Benign	Inflammatory Bowel Disease 1	NG_016275.1:g.11958A>G; NM_001558.3:c.475A>G; NP_001549.2:p.Ser159Gly	3135932	197197
NM_001558.4:c.172G>A	Lebanon	chr11:117988486	Likely Benign	Likely Pathogenic	Inflammatory Bowel Disease 28, Autosomal Recessive	NG_016275.1:g.7096G>A; NM_001558.4:c.172G>A; NP_001549.2:p.Glu58Lys	572945136	733184

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External Links

https://ghr.nlm.nih.gov/gene/IL10RA https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL10RA https://www.ncbi.nlm.nih.gov/gene/3587

Contributors

Pratibha Nair: 16.11.2020
Pratibha Nair: 12.05.2020
Pratibha Nair: 28.08.2019

Edit History

Pratibha Nair: 16.11.2020
Pratibha Nair: 12.05.2020
Pratibha Nair: 28.08.2019
Pratibha Nair: 07.12.2014

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