Autosomal recessive spinocerebellar ataxia-12 (SCAR12) is an extremely rare neurologic disorder which involves central, peripheral nervous system and other organs. It is characterized by onset of generalized seizures in infancy. The prominent clinical feature includes progressive incoordination of gait and poor coordination of hands, eyes and speech. Patients also have delayed psychomotor development, spasticity and intellectual disability. The age of onset and disease progression varies among affected individuals.
