AKAP6 gene encodes a protein belonging to the A-Kinase Anchor Proteins (AKAPs) family. Members of this family are responsible for binding to the regulatory subunit of the holoenzyme Protein Kinase A (PKA) and anchoring it to the nuclear membrane or sarcoplasmic reticulum. AKAP6 is responsible for maintaining a cAMP-responsive signaling complex consisting of PKA, PDE4D3 and EPAC1. Through this complex, the AKAP6 protein coordinates two coupled cAMP dependent loops. The protein is also believed to play a role in the positive regulation of cell growth, particularly in cardiac muscle cell development.