RAD51 Paralog D

Alternative Names

  • RAD51D
  • RAD51, S. cerevisiae, Homolog of, D
  • S. cerevisiae RAD51-Like 3
  • RAD51L3
  • TRAD
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OMIM Number

602954

NCBI Gene ID

5892

Uniprot ID

O75771

Length

29,315 bases

No. of Exons

11

No. of isoforms

8

Protein Name

DNA repair protein RAD51 homolog 4

Molecular Mass

35049 Da

Amino Acid Count

328

Genomic Location

chr17:35,092,208-35,121,522

Gene Map Locus
17q12

Description

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001142571.2:c.758A>G Lebanonchr17:35103294Benign, Likely BenignUncertain SignificanceBreast CancerNG_031858.1:g.21576A>G; NM_001142571.2:c.758A>G ; NP_001136043.1:p.Glu253Gly28363284138873
NM_002878.3:c.494G>A Lebanonchr17:35106468BenignUncertain SignificanceBreast CancerNG_031858.1:g.18402G>A; NM_002878.3:c.494G>A ; NP_002869.3:p.Arg165Gln4796033142159
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