Takayasu Arteritis

Alternative Names

  • Aortic Arch Syndrome
  • Young Female Arteritis
  • Pulseless Disease
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WHO-ICD-10 version:2010

Diseases of the circulatory system

Diseases of arteries, arterioles and capillaries

OMIM Number

207600

Mode of Inheritance

? Autosomal recessive vs. autoimmune

Description

Takayasu Arteritis (TA) is a rare inflammatory disease characterised by large-vessel vasculitis (blood vessel inflammation). It predominantly affects the aorta and the pulmonary artery causing occlusion or aneurysm. TA is also referred as 'pulseless disease' because of the difficulty in detecting pulses in the upper extremities, which may be caused due to vascular narrowing. In approximately 90% of cases, TA appears in patients younger than 30 years with a higher female: male ratio.

Takayasu Arteritis is known to be associated with human lymphocyte antigen (HLA) but the exact nature of how it develops is unknown.

Epidemiology in the Arab World

View Map
Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
207600.1BahrainFemale Vasculitis; Paresthesia; Dysarthria;...NM_005957.4:c.665C>T, NM_005957.4:c.1286A>C, NM_000789.4:c.2306-105_2306-104insTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCATACAGTCACTTTTHomozygousAutosomal, RecessiveAl Jishi et al. 2005 Patient is comorbid ...

Other Reports

Egypt

Sattar et al. (1985) reported four cases of Takayasu Arteritis in Arab women from Kuwait, Egypt and Palestine. All four patients were found to exhibit the antigens HLA-A2, A9, BW35, CW4, and DR7.

Iraq

Baumgartner et al. (2005) described a 14-year-old Iraqi girl with Takayasu Arteritis. The patient had a history of fever, fatigue, malaise and diffuse pain. Imaging studies showed aortic wall thickening, aortic arch dilatation, and reduction in the luminal diameters of the abdominal aorta and both subclavian arteries.

Kuwait

El-Reshaid et al. (1995) carried out a study involving 13 patients with Takayasu Arteritis (TA) to describe the clinical features and other determinants of the disease in Kuwait. Renal disease, secondary to isolated involvement of the abdominal aorta was a fairly common presentation, observed in four patients. Female preponderance and association of TA with other autoimmune diseases and primary hypercoagulable states, seen in other populations, was noted to be inconsonant with this patient group.

[See also: Egypt > Sattar et al. (1985)].

Lebanon

Atallah et al. (1998) reported on a series of 42 renal artery stenosis treated with percutaneous transluminal angioplasty (PTA) from January 1988 to June 1996. Among the 33 patients described, one patient had Takayasu arteritis.

Palestine

[See also: Egypt > Sattar et al. (1985)].

Tunisia

Ben Zineb et al. (1992) described a pregnant woman with Takayasu's arteritis and Crohn's disease.

Yemen

Almotarreb and Alabsi (2004) described a 29-year old man with Takayasu Arteritis (TA). This was the first reported case of TA diagnosed together with rheumatic heart disease in Yemen.

[Almotarreb A, Alabsi M. Takayasu's arteritis and rheumatic heart disease. Heart Views. 2004; 5(1):24-5.]

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