Motor delay; Delayed speech and language development; Microcephaly; Spasticity; Seizure; Ichthyosis; Failure to thrive; Joint contracture; Optic atrophy
Motor delay; Delayed speech and language development; Microcephaly; Spasticity; Seizure; Ichthyosis; Failure to thrive; Joint contracture; Optic atrophy; Global developmental delay; Sparse hair